Very rarely acceptable, still preferable to use he or she based on context, if no sufficient context is available use "the person in question" or the person's title. Using they/them facilitates the idea that gender and sex are insignificant, not to mention it's prone to causing confusion
I watched that clip before I even discovered E;R, imagine how surreal it was watching some old content from a channel I found and suddenly being hit by an info meme I saved years ago